Download Brain Ischemia by Eugene I. Gusev, Veronika I. Skvortsova PDF

By Eugene I. Gusev, Veronika I. Skvortsova

Ischemia is localized tissue anemia as a result of obstruction of the influx of arterial blood, hence mind ischemia is the situation the place inadequate blood is brought to the mind. Many physiological strategies happening within the mind severely rely on the country of its power metabolism. The nation of mind strength metabolism in flip will depend on the supply of oxygen and glucose to the mind through the bloodstream. even though it contains purely 2% of the whole bodyweight, the human mind consumes 20-25% of the oxygen and as much as 70% of the loose glucose taken in through the physique. The mind respires extra intensively than the other organ of the physique. The depth of oxygen intake via cortical mind tissue a lot exceeds the calls for of different tissues (5.43 mmol 02/g consistent with h as opposed to 3.06 and 4.02 mmol for center at relaxation and intensively operating, respectively, 2.4 mmol for kidneys, and 1.8 mmol for liver). Oxidative phosphorylation in mitochondria generates ninety five% of the adenosine triphosphate (ATP) that's shaped within the mind. therefore, it really is transparent why insufficiency of oxygen supply to mind cells adversely impacts mind functionality. Glucose is the most energy-providing substrate within the mind. the elemental pathway of its metabolism in neural tissue is cardio glycolysis.

Show description

Read Online or Download Brain Ischemia PDF

Best nonfiction_10 books

Social Competence in Developmental Perspective

What determines the focal point of a researcher's curiosity, the resources of concept for a research, or the variables scrutinized? If we have been to ascertain the antecedents of those judgements, they might definitely turn out to be injuries of circumstance--the own studies of the researcher, the foundation of early mentors, the impression of up to date colleagues--all tempered by way of the highbrow currents that nurture the researcher's hypotheses.

Additional resources for Brain Ischemia

Sample text

Moscow, pp. 5-44 (in Russian). 25. Lukyanova, L. , 1991, Advances in Science and Technology. Pharmacology and Therapeutic Agents. Moscow, 27: 5-25 (in Russian). 26. Lukjyanova, L. , 1996, In Adaptation Biology and Medicine (Shanina, B. , Ganguly, N. ) New Delhi. I: 261-279 (in Russian). 27. Lukyanova, L. , 1997, Bull Exp Bioi Med. 9: 244-254 (in Russian). 28. Lukyanova, L. , Balmukhanov, B. , Ugolev, A. , 1982, In Oxygen-Dependent Events in Cell and Cellular Functions. 30 I. 29. Lukyanova, L. , Chemobayeva, G.

Driscoll, B. , Law, M. , 1995, Proc Natl Acad Sci USA. 92: 4616-4620. 49. , Magistretti, P. , 1996, J Neurosci. 16: 877-885. 50. Ylasova, I. , Kutsov, G. , Lomakin, Yu. , 1999, The influence of hypoxia on neurons belonging to different brain structures in outliving slices. In Hypoxia: Mechanisms. Adaptation and Correclion. Moscow, 14 (in Russian). 51. Welsh, F. , O'Connor, M. , Marcy, Y. , 1982, Stroke. 1: 234-242. Chapter 4 The Glutamate-Calcium Cascade When glutamate is released from presynaptic terminals, it diffuses to the postsynaptic terminals where it binds to glutamate receptors, allowing Na+ influx that depolarizes the membrane.

1987, In Free Radicals and Biostabilizers. Sophia, 85. 36. Lukyanova, L. , Ylasova, I. , 1989, Bull Exp Bioi Med. 108 (9): 266-269 (in Russian). 37. Lukyanova, L. , Ylasova, I. , 1991, Advances in Science and Technology. Pharmacology and Therapeutic Agents. Moscow. 27: 164-176 (in Russian). 38. , Babsky, A. , Kondrashova, M. , 1988, In Pharmacological Correction ofHypoxic States. Moscow, pp. 45-46 (in Russian). 39. , Magistretti, P. , 1994, Proc Natl Acad Sci USA. 91: 10625-10629. 40. Popova, O.

Download PDF sample

Rated 4.48 of 5 – based on 23 votes

About admin